Crm1 Protein

Research Paper CRM1 Inhibition Sensitizes Drug Resistant ...
CRM1 (chromosome maintenance protein -1) is a ubiquitous protein that exports large prot eins (>40 kDa) from the nucleus to the cytoplasm. We found that small -molecule Selective Inhibitors of Nuclear Export (SINE) prevent CRM1-mediated ... Return Doc

The Drosophila Embargoed Gene Is Required For Larval ...
The Functional Homolog of Schizosaccharomyces Crm1 of the CRM1 protein is to maintain chromosome integ- perature (Fukuda et al. 1997). rity, because the first cold-sensitive fission yeast (Schizo- A further source of S. pombe crm1 alleles was a screen ... Fetch Doc

Degradation Of Specific Nuclear Proteins Occurs In The ...
Although the exportin protein encoded by CRM1/XPO1 plays a central role in nuclear export, other factors may also facilitate the export of specific classes of nuclear substrates of the proteasome. It is noteworthy that ... Access Full Source

Expression Of CRM1 And Her-2/neu And Their Clinical Signific ...
Expression of CRM1 and Her-2/neu and Their Clinical Signific ance in Gastric Cancer 1Xiaoxiao Sun, 2Jianzhong Qiu, The human nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 (CRM1) ... Get Content Here

Structural Determinants And Mechanism Of Mammalian CRM1 Allostery
Structural Determinants and Mechanism of Mammalian CRM1 Allostery CRM1-RanGTP-SPN1 ternary complex (Protein Data Bank [PDB] ID: 3GJX) and on the same assembly structure after removing either SPN1 or/ and RanGTP. Global conformational changes were monitored ... Access This Document

Crm1 (XpoI) Dependent Nuclear Export Of The Budding Yeast ...
Crm1 (XpoI) dependent nuclear export of the budding yeast transcription factor yAP-1 is sensitive to oxidative stress Shusuke Kuge,1,* Takashi Toda2, Narushi Iizuka3 and Akio Nomoto1 wild-type levels of the Crm1 protein in a methionine-depleted medium (Fig. 1A, lanes 1 and 2). However, a ... Fetch Doc

Stimulated Expression Of MRNAs In Activated T Cells Depends ...
Depends ona Functional CRM1 NuclearExportPathway Sylvia Schu¨tz1, Jan Chemnitz2, Christiane Spillner3, serve as a tissue-specific adapter protein for CRM1-dependent transport of specific mRNA molecules. Here, we used cDNA representational difference analysis ... Get Doc

CRM1 Expression And Purification - Uni-goettingen.de
CRM1 Expression and Purification. Also: CAS . Exportin t. Plasmid: pQE60 His-CRM1. pQE60 CRM1-Transform CRM1 clones into TG1 cells (TG1 is very important!). ... Visit Document

Nuclear Entry And CRM1-dependent Nuclear Export Of The Rous ...
The Gag protein, that of transient nuclear localization. CRM1 nuclear export pathway, based on observations that treat-ment of virus-expressing cells with leptomycin B resulted in the redistribution of Gag proteins from the cytoplasm to the nucleus. ... View Doc

Nature Neuroscience : Nuclear Export Inhibitors Avert ...
Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination. Jeffery D Haines et al (2015), Nature Neuroscience http://dx.doi.org/10.1038/nn.3953 Axonal damage has been associated with aberrant protein trafficking. We examined a newly characterized ... View Video

Biology 2012 OPEN ACCESS Biology - MDPI
Biology 2012, 1, 165-174; doi:10.3390/biology1020165 biology ISSN 2079-7737 www.mdpi.com/journal/biology Rev binds RRE-RNA and docks it to the cellular export protein, CRM1 (chromosome region maintenance 1) [24,25]. The RRE-RNA-Rev-CRM1 complex is then ... Fetch Content

IRF5 - Wikipedia
Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene. ... Read Article

Cyclin E1 - Wikipedia
G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene. Function. The protein encoded by this gene belongs to the highly conserved cyclin ... Read Article

Leptomycin B: Results And Discussion An Important Tool For ...
An Important Tool for the Study of Nuclear Export Nishi, K. et al. Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome struc-ture and gene expression. ... Return Doc

RanBP3 Enhances Nuclear Export Of Active -catenin ...
Nomatous polyposis coli protein and CRM1. We conclude that RanBP3 is a direct export enhancer for -catenin, independent of its role as a CRM1-associated nuclear export cofactor. Introduction The Wnt signaling pathway regulates a variety of processes ... Doc Viewer

Chromatin-prebound Crm1 Recruits Nup98-HoxA9 Fusion To Induce ...
Oka et al. further found that a protein called Crm1, which is well known as a nuclear export factor that carries molecules out of the nucleus through the pore, is already bound to the Hox cluster genes in the nucleus and recruits the Nup98-HoxA9 protein. ... Retrieve Content

TARGETED INHIBITION OF CHROMOSOMAL MAINTENANCE REGION PROTEIN ...
Region protein (crm1) potently suppresses growth of human neuroblastoma cell line models. title: crm1 poster - aacr 2013 created date: 4/8/2013 2:00:30 am ... Read Here

Nucleoporin 214 - Wikipedia
Nucleoporin 214 (Nup2014) is a protein that in humans is encoded by the NUP214 gene. Function. The nuclear pore complex is a massive structure that extends across the CRM1; NXF1, and; NXF2, and; ZFP36. References Further ... Read Article

Novel Reversible Selective Inhibitor Of Nuclear Export Shows ...
Novel reversible selective inhibitor of nuclear export shows that CRM1 is a target in colorectal cancer cells The over-expression of CRM1 protein has been found in various *Correspondence to: Xuejiao Liu; Email: liuxuejiao0923@126.com ... Retrieve Content

CRM1 Controls The Composition Of Nucleoplasmic Pre- SnoRNA ...
CRM1 controls the composition of nucleoplasmic pre- The observation that each core protein pulled down U3 was evidence that CRM1 inhibition does not affect assembly. The potential problem with this interpretation comes with ... Doc Retrieval

A Synthetic HIV-1 Rev Inhibitor Interfering With The CRM1 ...
A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export cent protein; PKI, protein kinase inhibitor; LMB, leptomycin B. ... Retrieve Full Source

Optogenetic Control Of Nuclear protein Export - YouTube
Optogenetic control of nuclear protein export. Dominik Niopek et al (2016), Nature Communications http://dx.doi.org/10.1038/ncomms10624 Active nucleocytoplas ... View Video

NXT1, A Novel Influenza A NP Binding Protein, Promotes The ...
Viruses Article NXT1, a Novel Influenza A NP Binding Protein, Promotes the Nuclear Export of NP via a CRM1-Dependent Pathway Nopporn Chutiwitoonchai and Yoko Aida * ... View Document